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Letters
November 17, 2010

Treating Sternal Wound Infections After Cardiac Surgery With an Implantable Gentamicin-Collagen Sponge—Reply

JAMA. 2010;304(19):2123-2124. doi:10.1001/jama.2010.1614

In Reply: Our study and a companion study in colorectal surgery1 are 2 large phase 3 trials targeting separate common surgical procedures; both clearly failed to demonstrate efficacy of use of the gentamicin-collagen sponge. These are not the first trials to fail to show efficacy. Dr Corn cites 2 positive European trials.2,3 However, the study by Eklund et al was negative as indicated by its authors who wrote that their “ . . . prospective, randomized study showed no significant difference between infection rates in the two groups.”2

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