From the Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif, and Stanford University, Stanford, Calif.
Following dramatic newspaper and television accounts that clinical laboratories
often failed to detect abnormal Papanicolaou (Pap) smears, Congress amended
the Clinical Laboratory Improvement Act (CLIA) in 1988. CLIA '88 included
provisions designed to reduce the false-negative rate for Pap smears by detecting
and correcting deficiencies in laboratory procedures.1
Most laboratories have complied with the CLIA Pap smear requirements by taking
a second look at ("rescreening") 10% of all Pap smears initially classified
as "within normal limits."
Garber AM. Making the Most of Pap Testing. JAMA. 1998;279(3):240-241. doi:10.1001/jama.279.3.240