From the Departments of Medicine (Dr O'Connor) and Psychiatry (Dr Kosten), Yale University School of Medicine, New Haven, Conn.
Objective.— To review the scientific literature on the effectiveness of rapid opioid
detoxification (RD) (opioid withdrawal precipitated by naloxone hydrochloride
or naltrexone) and ultrarapid opioid detoxification (URD) (opioid withdrawal
precipitated by naloxone or naltrexone under anesthesia or heavy sedation)
Data Sources.— The MEDLINE database was searched from 1966 through 1997 using the indexing
terms naloxone, naltrexone, substance dependence,
and substance withdrawal syndrome. Additional data
sources included bibliographies of papers identified on MEDLINE and bibliographies
in textbooks on substance abuse.
Study Selection.— Inclusion criteria were studies of RD or URD, pharmacologic protocols
specified, and clinical outcomes specified and reported. Exclusion criteria
were unpublished data, data not in peer-reviewed journals, abstract-only publications,
and review articles.
Data Extraction.— The methodologic characteristics of studies were extracted by the authors
and summarized according to key components of research design concerning subject
characteristics, therapy allocation, and outcomes assessed.
Data Synthesis.— A qualitative analysis was performed on the 12 studies of RD and the
9 studies of URD identified in our search. The RD studies enrolled 641 subjects
(range for individual studies, 1-162): 7 were inpatient studies, and the protocols
varied considerably, as did the outcomes assessed. Three RD studies included
a control group, 2 used a randomized design, and 3 reported outcomes beyond
12 days. The URD studies enrolled 424 subjects (range for individual studies,
6-300): all were inpatient studies, the detoxification and anesthesia protocols
varied, 3 included a control group, 2 used a randomized design, and 2 reported
outcomes for URD beyond 7 days.
Conclusions.— The existing literature on RD and URD is limited in terms of the number
of subjects evaluated, the variation in protocols studied, lack of randomized
design and use of control groups, and the short-term nature of the outcomes
reported. Further research is needed using more rigorous research methods,
longer-term outcomes, and comparisons with other methods of treatment for
O'Connor PG, Kosten TR. Rapid and Ultrarapid Opioid Detoxification Techniques. JAMA. 1998;279(3):229-234. doi:10.1001/jama.279.3.229