From the Division of International Medicine and Infectious Diseases, New York Hospital–Cornell Medical Center, New York, NY.
Significant progress has been made in the development of effective antiretroviral
drug regimens for the treatment of human immunodeficiency virus (HIV) disease.
Combinations of antiretroviral agents have been shown to decrease HIV RNA
levels to the limit of detection of current viral load assays in a majority
of patients for periods of months to years. These profound reductions in viral
load reflect significant decreases in viral replication and appear to limit
the emergence of resistant viral phenotypes, thereby promoting durable antiretroviral
Gulick RM. HIV Treatment StrategiesPlanning for the Long Term. JAMA. 1998;279(12):957-959. doi:10.1001/jama.279.12.957