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Health Agencies Update
May 28, 2014

FDA Warns of Risks Related to Epidural Injections

Author Affiliations

Copyright American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2014;311(20):2057. doi:10.1001/jama.2014.5759

Patients receiving epidural injections of corticosteroids for neck, back, or limb pain are at risk of rare but serious adverse events, including blindness, stroke, paralysis, and death, according to a US Food and Drug Administration (FDA) warning.

Epidural injections of corticosteroids are a common treatment offered to patients who experience back pain, neck pain, or pain that radiates to the arms and legs. However, such injections are not FDA approved, and there is limited evidence backing their safety or effectiveness, according to the agency. A review of data from the FDA Adverse Event Reporting System found cases of death, spinal cord infarction, paraplegia, quadriplegia, cortical blindness, stroke, seizures, nerve injury, and brain swelling in patients who had received epidural steroid injections. These events occurred within minutes to 2 days after injection. According to the FDA, many of the patients did not recover from these injuries.

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