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Clinical Trials Update
May 28, 2014

Insomnia Increases Stroke Risk

JAMA. 2014;311(20):2056. doi:10.1001/jama.2014.5275

People with insomnia may be more likely to experience a stroke compared with people who sleep well, a risk that is especially pronounced among young adults, suggests a retrospective cohort study. The study is based on a review of claims data from 21 438 people with insomnia and 64 314 age- and sex-matched controls in Taiwan (Wu M-P et al. Stroke. 2014;45[5]:1349-1354.

The researchers compared the 2 groups of participants (none of whom had a previous stroke or sleep apnea) over the subsequent 4 years and found that the incidence of stroke was 8 times higher among those who had been diagnosed as having insomnia between ages 18 years and 34 years. The insomnia-related stroke risk continually decreased for those diagnosed with insomnia after age 34 years, but in any age group, those with insomnia had a higher risk of stroke than noninsomniacs. Older age, diabetes mellitus, hypertension, atrial fibrillation, more severe insomnia, and lower socioeconomic status were also significantly associated with increased stroke risk. Among those with insomnia, women had a 28% lower risk of stroke compared with men.

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