From the Department of Internal Medicine, University of Utah Health Science Center, Salt Lake City.
Implantation of foreign materials in the form of fixation devices and
prosthetic joints has revolutionized the orthopedic surgical field in the
last decades. These indisputable technological advances and sophisticated
devices, although usually highly successful and devoid of complications, pose
a challenging problem if they succumb to infection. Effective treatment of
infections of implanted orthopedic devices has been extremely difficult regardless
of repeated revision surgeries and prolonged courses of antimicrobials.
Zavasky D, Sande MA. Reconsideration of RifampinA Unique Drug for a Unique Infection. JAMA. 1998;279(19):1575-1577. doi:10.1001/jama.279.19.1575