JAMA Clinical Evidence Synopsis
June 4, 2014

Prophylactic Antibiotic Therapy in Chronic Obstructive Pulmonary Disease

Author Affiliations
  • 1Day Unit, Department of Respiratory Medicine, Montreal Chest Institute, Montreal, Quebec, Canada
  • 2Department of Medicine, The University of Auckland, Auckland, New Zealand

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JAMA. 2014;311(21):2225-2226. doi:10.1001/jama.2014.4929

Clinical Question  Is prophylactic antibiotic treatment associated with fewer exacerbations or improved health-related quality of life (HRQOL) in patients with chronic obstructive pulmonary disease (COPD)?

Bottom Line  Continuous macrolide antibiotic use for prophylaxis was associated with a clinically significant reduction in COPD exacerbations. Pulsed antibiotic use was not associated with benefit. Continuous and pulsed antibiotics were associated with improved HRQOL, but this was not clinically significant.