In Reply Dr Nikolaidou and colleagues correctly pointed out that a 27% reduction in the composite outcome of death and major disability was identified (odds ratio, 0.73 [95% CI, 0.55-0.97], P = .03) at the 3-month posttreatment follow-up among patients who received antihypertensive treatment 24 hours or longer after stroke onset.
The P value for homogeneity (interaction test) among 3 subgroups by time from stroke symptom onset to antihypertensive treatment (<12, 12-23, and ≥24 hours) was .03 (presented in Figure 4 of our article). We agree that the finding from a subgroup analysis can only be used to generate a study hypothesis, which will be tested in future randomized clinical trials.
He J, Zhang Y, Chen J. Antihypertensive Therapy After Acute Ischemic Stroke—Reply. JAMA. 2014;311(22):2334-2335. doi:10.1001/jama.2014.5167