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The World in Medicine
September 9, 1998

No Survival Advantage

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JAMA. 1998;280(10):873. doi:10.1001/jama.280.10.873

High-dose chemotherapy accompanied by infusions of blood stem cells apparently offers no survival advantage over standard chemotherapy for women with breast cancer.

A study by researchers at the Netherlands Cancer Institute in Amsterdam included 97 women with breast cancer that had spread to the lymph nodes. After three courses of chemotherapy and surgery, 81 women whose tumors responded to therapy by shrinking or not growing larger were randomized to receive a fourth course of standard chemotherapy or a high-dose regimen and blood stem cells.

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