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September 16, 1998

Comparing Treatments for Localized Prostate Cancer—Persisting Uncertainty

Author Affiliations

From the Prostate and Urology Center, Louis A. Weiss Memorial Hospital, Chicago, Ill.

JAMA. 1998;280(11):1008-1010. doi:10.1001/jama.280.11.1008

Year after year, uncontrolled studies are published that attempt to compare the various treatments for localized prostate cancer. Almost uniformly, more questions are raised than answered and the debate goes on: Is surgery the most effective treatment? How comparable are surgery, external radiotherapy, and interstitial radiation delievered by implant (brachytherapy)? What is the marginal benefit of any treatment over conservative management followed by delayed hormone therapy? Two articles in this issue of THE JOURNAL, one by Albertsen et al1 and one by D'Amico et al,2 add more information but still leave physicians and their patients without definitive answers to these pressing questions.

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