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Comment & Response
June 18, 2014

Number of Human Papillomavirus Vaccine Doses and Condyloma

Author Affiliations
  • 1National Cancer Institute, Bethesda, Maryland
JAMA. 2014;311(23):2439. doi:10.1001/jama.2014.5009

To the Editor Dr Herweijer and colleagues1 presented short-term data on the association of quadrivalent human papillomavirus (HPV) vaccine with the risk of condyloma by number of vaccine doses. Their primary analysis showed that fewer doses may be associated with a reduction in condyloma risk, albeit with less reduction than 3 doses. Yet their supplemental data suggested that 1 and 2 doses may be associated with comparable risk reduction as 3 doses. We would like to address this inconsistency.

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