[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Views 346
Citations 0
Comment & Response
June 18, 2014

Withdrawal of Personal Genome Service—Reply

Author Affiliations
  • 1Yale University, New Haven, Connecticut
JAMA. 2014;311(23):2441-2442. doi:10.1001/jama.2014.5584

In Reply Dr van Rossum raises concern about our suggestion that 23andMe’s PGS could be used under the supervision of a physician once the analytical validity of the test has been established. We wholeheartedly agree that data describing the clinical validity of genetic tests, like the PGS, would clarify their role in medical practice. The clinical validity of the PGS consists of 2 components: the test must predict an individual’s risk of disease using data derived from studies of genetic association, and once this is done accurately, physicians must know how to use this information in the clinical setting. Van Rossum rightly points out that the PGS falls short on both of these components.

First Page Preview View Large
First page PDF preview
First page PDF preview