From the Department of Neurology, Mayo Clinic, Rochester, Minn.
Pain resulting from diffuse and focal neuropathies, such as painful diabetic neuropathy (PDN) and
postherpetic neuralgia (PHN), is a relatively common but difficult to
manage clinical problem. Neuropathy occurs in more than 50% of
patients with diabetes who have been hyperglycemic for more than 15
years,1 and about 10% of patients with diabetic neuropathy
are troubled with persistent dysesthesias or pain. Unfortunately, drug
treatment for PDN is often unsatisfactory, as eloquently demonstrated
by the large number of drugs that patients will have taken in an
attempt to seek relief.
Low PA, Dotson RM. Symptomatic Treatment of Painful Neuropathy. JAMA. 1998;280(21):1863-1864. doi:10.1001/jama.280.21.1863