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JAMA Clinical Evidence Synopsis
June 25, 2014

Topical and Systemic Antimicrobial Therapy for Venous Leg Ulcers

Author Affiliations
  • 1School of Healthcare, Baines Wing, University of Leeds, England
  • 2Cochrane Wounds Group, Department of Health Sciences, University of York, York, England
  • 3Department of Medicine, University of Washington, Seattle
  • 4Department of Infectious Diseases, University of Geneva, Geneva, Switzerland
  • 5Green Templeton College, University of Oxford, Oxford, England
JAMA. 2014;311(24):2534-2535. doi:10.1001/jama.2014.4574
Abstract

Clinical Question  Is treatment with topical or systemic antimicrobial agents associated with better venous leg ulcer healing compared with usual care (dressings and bandages without antimicrobials) or an alternative topical or systemic antimicrobial agent?

Bottom Line  Available evidence, from underpowered pooled data, neither supports nor refutes an association of systemic antibiotic therapy with improved venous leg ulcer healing. Among topical antimicrobials, cadexomer iodine may be associated with better healing compared with usual care.

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