In December 1997, at Medicine Grand Rounds, Dr Mark
Peppercorn, MD, discussed the range of treatment options for ulcerative
At that time, Mrs F, a 66-year-old woman with
loose, bloody bowel movements and a diagnosis of ulcerative colitis,
expressed concern about usual medications due to severe allergies.
Cortenemas had lost their efficacy, and prednisone prescribed for
severe asthma was of uncertain benefit for her symptoms of ulcerative
colitis. Dr Peppercorn felt her disease was not severe enough to
justify colectomy, but he did believe a trial with topical aspirin
therapy was warranted as a next step.
Parker RA, Hartman EE. A 66-Year-Old Woman With Ulcerative Colitis, 1 Year Later. JAMA. 1998;280(24):2118. doi:10.1001/jama.280.24.2118