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Clinical Crossroads
December 23/30, 1998

A 66-Year-Old Woman With Ulcerative Colitis, 1 Year Later

JAMA. 1998;280(24):2118. doi:10.1001/jama.280.24.2118

In December 1997, at Medicine Grand Rounds, Dr Mark Peppercorn, MD, discussed the range of treatment options for ulcerative colitis.1 At that time, Mrs F, a 66-year-old woman with loose, bloody bowel movements and a diagnosis of ulcerative colitis, expressed concern about usual medications due to severe allergies. Cortenemas had lost their efficacy, and prednisone prescribed for severe asthma was of uncertain benefit for her symptoms of ulcerative colitis. Dr Peppercorn felt her disease was not severe enough to justify colectomy, but he did believe a trial with topical aspirin therapy was warranted as a next step.

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