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JAMA Clinical Evidence Synopsis
July 9, 2014

Antiepileptic Drugs for Neuropathic Pain and Fibromyalgia

Author Affiliations
  • 1Pain Research and Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, England
  • 2Department of Anaesthesia, Intensive Care Medicine, Emergency Medicine, and Pain Medicine, Helsinki University Central Hospital, Helsinki, Finland
  • 3Institute of Clinical Medicine, University of Helsinki, Finland
JAMA. 2014;312(2):182-183. doi:10.1001/jama.2014.6336
Abstract

Clinical Question  Are antiepileptic drugs associated with reduced pain intensity in patients with neuropathic pain or fibromyalgia?

Bottom Line  In treating diabetic neuropathy and postherpetic neuralgia compared with placebo, gabapentin and pregabalin are associated with a modest increase in the number of patients experiencing meaningful pain reduction. In treating fibromyalgia, compared with placebo, pregabalin alone is associated with a small increase in the number of patients experiencing meaningful pain reduction. There is insufficient evidence for other antiepileptics.

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