A single dose of ketamine given in an intravenous (IV) infusion resulted in the rapid reduction of symptoms of posttraumatic stress disorder (PTSD) in a proof-of-concept, randomized, double-blind study of 41 patients with chronic PTSD (Feder A et al. JAMA Psychiatry. 2014;71:681-688).
For each procedure day, patients were assigned to receive a single IV infusion of ketamine hydrochloride or midazolam, administered over 40 minutes. The order of infusions was randomly assigned, and administrations were made 2 weeks apart. Midazolam was chosen as the active placebo because its pharmacokinetic parameters and nonspecific behavioral effects are similar to those of ketamine.
Slomski A. Ketamine Effective in Treating PTSD. JAMA. 2014;312(4):327. doi:10.1001/jama.2014.9149