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Clinical Trials Update
July 23/30, 2014

Antidepressants in Pregnancy Don’t Lead to Cardiac Defects in Infants

JAMA. 2014;312(4):327. doi:10.1001/jama.2014.9150

Antidepressant use during the first trimester of pregnancy is not associated with an increased risk of congenital cardiac malformations in infants, according to results of a cohort study of 949 504 women in the Medicaid program (Huybrechts K et al. N Engl J Med. 2014;370[25]:2397-2407). The study refutes previous studies that have found an association between paroxetine use and right ventricular outflow tract obstruction and between sertraline use and ventricular septal defects.

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