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Antidepressant use during the first trimester of pregnancy is not associated with an increased risk of congenital cardiac malformations in infants, according to results of a cohort study of 949 504 women in the Medicaid program (Huybrechts K et al. N Engl J Med. 2014;370:2397-2407). The study refutes previous studies that have found an association between paroxetine use and right ventricular outflow tract obstruction and between sertraline use and ventricular septal defects.
Slomski A. Antidepressants in Pregnancy Don’t Lead to Cardiac Defects in Infants. JAMA. 2014;312(4):327. doi:10.1001/jama.2014.9150