Author Affiliation: Department of Orthopaedic Surgery, University of Minnesota, Minneapolis.
Edited by Thomas C. Jefferson, MD, JAMA Fishbein Fellow.
Osteoarthritis is not simply a degenerative disorder. Rather, it is a complex derangement of articular
surfaces that involves the loss of normal collagen architecture
followed by an attempt by chondrocytes to produce replacement
cartilage. The replacement surface is less resistant to wear than the
original. Over time, full-thickness cartilage loss may develop on the
articular surfaces. Symptoms of osteoarthritis include joint pain,
typically worse with use and eased with rest, and joint stiffness after
nonuse. The pain can become persistent.
LaPrade RF, Swiontkowski MF. New Horizons in the Treatment of Osteoarthritis of the Knee. JAMA. 1999;281(10):876-878. doi:10.1001/jama.281.10.876