Author Affiliation: Office of the Deputy Director for Clinical Care, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Md.
Grand Rounds at the Clinical Center of the National Institutes of
Health Section Editors: John I. Gallin, MD, the Clinical Center
of the National Institutes of Health, Bethesda, Md; David S. Cooper,
MD, Contributing Editor, JAMA.
Postexposure chemoprophylaxis is
now recommended for health care workers who experience certain kinds of
occupational exposures to the human immunodeficiency virus (HIV) in the
workplace. Substantial information has emerged that supports but does
not prove the efficacy of antiretroviral agents in preventing HIV
infection after occupational exposure. This article reviews the data
that have accrued in the past 8 years that bear directly on this
question and describes a systematic approach to the clinical management
of health care workers occupationally exposed to HIV.
Henderson DK. Postexposure Chemoprophylaxis for Occupational Exposures to the Human Immunodeficiency Virus. JAMA. 1999;281(10):931-936. doi:10.1001/jama.281.10.931