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Comment & Response
August 6, 2014

Age-Adjusted D-Dimer Cutoff Levels and Pulmonary Embolism—Reply

Author Affiliations
  • 1Division of Angiology and Hemostasis, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
  • 2Department of Vascular Medicine, University of Groningen, Groningen, the Netherlands
  • 3Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
JAMA. 2014;312(5):557. doi:10.1001/jama.2014.7607

In Reply Mr Colombo and colleagues asked whether all D-dimer assays perform equally when using the age-adjusted D-dimer cutoff to rule out pulmonary embolism or whether different patient characteristics could explain the variability in the proportion of patients with negative D-dimer levels.

We favor the latter hypothesis. There were important differences in patient characteristics across assay subgroups. For example, mean age varied from 58 years in the VIDAS D-Dimer Exclusion group to 67 years in the Tina-quant D-Dimer group.

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