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To the Editor Dr Pisansky and colleagues1 did not find any beneficial effect of daily tadalafil administration in preventing erectile dysfunction (ED) in men treated with radiotherapy for prostate cancer. Concerns about the methodology of this study parallel those raised after previous trials testing penile rehabilitation after radical prostatectomy. These include inadequate patient selection,1 short-term follow-up,2 and possibly improper tadalafil administration.3
Castiglione F, Montorsi F, Briganti A. Tadalafil for Erectile Dysfunction Prevention After Radiotherapy for Prostate Cancer. JAMA. 2014;312(7):748. doi:10.1001/jama.2014.7920