In Reply Based on published studies,1- 3 we think there are clear benefits for statins for the primary and secondary prevention of stroke. The Cholesterol Treatment Trialists’ Collaboration4 meta-analysis from 2010 showed a hazard ratio of 0.85 (95% CI, 0.80-0.90) for stroke per 1-mmol/L reduction of low-density lipoprotein cholesterol with statin use vs placebo; 0.80 (99% CI, 0.73-0.88) for ischemic stroke, 1.10 (99% CI, 0.86-1.42) for hemorrhagic stroke, and 0.88 (99% CI, 0.76-1.02) for unknown stroke type. Although heterogeneity between primary and secondary prevention trials was not reported, similar patterns appeared to be present for primary and secondary prevention trials.
Muntner P, Howard G, Safford MM. Statins and Ischemic Stroke—Reply. JAMA. 2014;312(7):750. doi:10.1001/jama.2014.8367