The Medical Literature
May 19, 1999

Users' Guides to the Medical LiteratureXVI. How to Use a Treatment Recommendation

Author Affiliations

Author Affiliations: Departments of Clinical Epidemiology and Biostatistics (Drs Guyatt, Sinclair, and Cook), Medicine (Drs Guyatt and Cook), and Pediatrics (Dr Sinclair), McMaster University, Hamilton, Ontario; and Department of Social and Preventive Medicine, University of Queensland Medical School, Herston QLD, Australia (Dr Glasziou).


Users' Guides to the Medical Literature Section Editor: Drummond Rennie, MD, Deputy Editor (West),JAMA.

JAMA. 1999;281(19):1836-1843. doi:10.1001/jama.281.19.1836

Clinicians can often find treatment recommendations in traditional narrative reviews and the discussion sections of original articles and meta-analyses. Making a treatment recommendation involves framing a question, identifying management options and outcomes, collecting and summarizing evidence, and applying value judgments or preferences to arrive at an optimal course of action. Each step in this process can be conducted systematically (thus protecting against bias) or unsystematically (leaving the process open to bias). Clinicians faced with a plethora of recommendations may wish to attend to those that are less likely to be biased. Therefore, we propose a hierarchy of rigor of recommendations to guide clinicians when judging the usefulness of particular recommendations. Recommendations with the highest rigor consider all relevant options and outcomes, include a comprehensive collection of the methodologically highest quality data with an explicit strategy for summarizing the data (that is, a systematic review), and make an explicit statement of the values or preferences involved in moving from evidence to action. High rigor recommendations come from systematically developed, evidence-based practice guidelines or rigorously conducted decision analyses. Systematic reviews, which typically do not consider all relevant options and outcomes or make the preferences underlying recommendations explicit, offer intermediate rigor recommendations. Traditional approaches in which the collection and assessment of evidence remains unsystematic, all relevant options and outcomes may not be considered, and values remain implicit, provide recommendations of weak rigor. In an era in which clinicians are barraged by recommendations as to how to manage their patients, this hierarchy provides a potentially useful set of guides.