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Lab Reports
September 3, 2014

Targeting Malaria Parasites That Hide in Bone Marrow

JAMA. 2014;312(9):882. doi:10.1001/jama.2014.10665

Immature forms of the parasite that causes malaria can sequester themselves outside the blood vessels in the bone marrow of infected patients to evade immune detection, researchers report (Joice R et al. Sci Transl Med. 2014;6[244]:244re5).

Harvard School of Public Health investigators and their colleagues analyzed tissues from autopsies of children who died of malaria to identify and characterize sites of Plasmodium falciparum accumulation.

The asexual stage of the parasite’s life cycle, when it multiplies profusely, occurs in red blood cells. But a small subset of parasites that develop into male and female sexual forms called gametocytes (which later mature and undergo fertilization after transmission to mosquitoes through the blood) reside in the bone marrow.

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