To the Editor The study by Dr Chamberlain and colleagues1 found that lorazepam was not more efficacious than diazepam for children with status epilepticus. We would appreciate further clarification regarding analysis of outcomes with reference to age and etiology.
We noted the high percentage of participants with febrile convulsions, especially within the younger age groups (3 months-<3 years and 3 years-<13 years). We also noted that in the age group older than 13 years there appeared to be more children who responded within 10 minutes to lorazepam (90.9%) than to diazepam (69.2%). It is therefore possible that lorazepam might be more effective for nonfebrile seizures in older children, but this analysis was limited by small numbers of patients.
Poulton A, Rai DK, Venter K. Treatments for Pediatric Status Epilepticus. JAMA. 2014;312(9):962. doi:10.1001/jama.2014.8745