Author Affiliations: Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore.
estrogen replacement therapy (ERT) or hormone replacement therapy (HRT)
increase the risk of breast cancer? This question is still being asked
today, even though more than 5 decades of experience with this therapy
and scores of epidemiological studies addressing the issue are
available. This important question refuses to go away, despite a lack
of direct evidence supporting a causal association. It is a question
that remains timely because of societal concerns about breast cancer
and the large numbers of women who currently use HRT. And, it is a
question that continues to be addressed in the medical literature and
lay media because of the commonly held belief that estrogens in some
way must cause breast cancer.
Bush TL, Whiteman MK. Hormone Replacement Therapy and Risk of Breast Cancer. JAMA. 1999;281(22):2140-2141. doi:10.1001/jama.281.22.2140