In Reply Drs Wong and Jolepalem and Dr Hofman and colleagues question the value of PET after preoperative chemotherapy. In our trial, a baseline CT was used to decide if the patient was a candidate for hepatic surgery. Most patients (70%) had received prior chemotherapy, usually adjuvant, for their primary treatment and often at a time and place remote from study enrollment. Patients were considered eligible 4 weeks after their last chemotherapy dose. This was a real-life study and reflects standard referral patterns. It does not seem in a patient’s best interest to delay a PET-CT for many months to achieve better resolution of the test.
Moulton C, Gulenchyn K, Levine MN. PET Screening for Metastatic Colorectal Adenocarcinoma—Reply. JAMA. 2014;312(12):1256-1257. doi:10.1001/jama.2014.9853