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September 24, 2014

From JAMA’s Daily News Site

JAMA. 2014;312(12):1183. doi:10.1001/jama.2014.12705

Older adults treated with atypical antipsychotic drugs are at increased risk of kidney injury, according to a new study.

Use of atypical antipsychotics is associated with a range of adverse effects that may contribute to kidney injury, including hypotension, pneumonia, heart attack, and the breakdown of muscle tissue. But the extent of the potential kidney risk has been unclear.

To assess the risk of kidney injury within 90 days, researchers conducted a cohort study comparing nearly 98 000 patients aged 65 years or older receiving a new atypical antipsychotic prescription with an equal number of matched controls. Patients who received an atypical antipsychotic medication were more likely to be hospitalized with a kidney injury. Use of the medication was also associated with low blood pressure, urine retention, and death.

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