In monkeys infected with deadly Marburg virus (MARV), a pathogen that is closely related to Ebola virus, treatment with a small interfering RNA molecule encased in a lipid nanoparticle was effective, even after signs of illness were detectable (Thi EP et al. Sci Transl Med. 2014;6:250ra116). All 16 macaques that received treatment beginning at 30 to 45 minutes, 1 day, 2 days, or 3 days after infection survived, while all 5 mock-treated control animals died between days 7 and 9 after infection.
Hampton T. Postexposure Marburg Treatment Effective in Monkeys. JAMA. 2014;312(13):1291. doi:10.1001/jama.2014.13084