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Comment & Response
October 8, 2014

Use of Hemodynamic Algorithm After Gastrointestinal Surgery—Reply

Author Affiliations
  • 1Queen Mary University of London, London, England
  • 2Integrative Physiology and Critical Illness Group, University of Southampton, Southampton, England

Copyright 2014 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2014;312(14):1471. doi:10.1001/jama.2014.10366

In Reply Drs Saugel and Reuter challenge the description of the OPTIMISE trial as a pragmatic trial. As applied to clinical trials, the term pragmatic has a particular meaning. Pragmatic trials are designed to evaluate the clinical effectiveness of a treatment in the context of routine clinical practice.1 This distinguishes them from explanatory trials, which are designed to evaluate the efficacy of a treatment under ideal conditions.

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