[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.161.216.242. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Views 565
Citations 0
Comment & Response
October 15, 2014

Benefits and Risks Associated With Thrombolysis for Pulmonary Embolism—Reply

Author Affiliations
  • 1Division of Cardiology, St Luke’s-Roosevelt Hospital, New York, New York
  • 2Cardiovascular Medicine Division, University of Pennsylvania Perelman School of Medicine, Philadelphia
JAMA. 2014;312(15):1589-1590. doi:10.1001/jama.2014.10789

In Reply Dr Bradford and colleagues suggest that the Peto method of determination of pooled ORs may be flawed because the event rates for mortality in pulmonary embolism trials were approximately 3%. However, at event rates less than 5%, the Peto method provides the least biased estimates of treatment effect when compared with the corrected Mantel-Haenszel, DerSimonian-Laird, and inverse-variance ORs.1

First Page Preview View Large
First page PDF preview
First page PDF preview
×