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Health Agencies Update
October 22/29, 2014

NIH Funds Creation of Database of Cellular Signatures

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Copyright 2014 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2014;312(16):1625. doi:10.1001/jama.2014.14460

Building on a successful 3-year pilot project, the National Institutes of Health (NIH) has awarded more than $64 million to 6 research institutions to create the Library of Integrated Network-based Cellular Signatures (LINCS), a database of human cellular responses to influences such as drugs, genetic factors, and environmental changes that can disrup cells (

Researchers at the 6 centers will measure the molecular and biochemical responses of cells and use computer analyses to identify common patterns, or signatures, in these responses. LINCS data will be freely available to all scientists. The project will help researchers better understand cellular processes and develop therapies to restore altered pathways and networks to their normal states.

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