[Skip to Content]
[Skip to Content Landing]
Views 1,187
Citations 0
Comment & Response
October NaN, 2014

Insulin vs Sulfonylureas for Second-Line Diabetes Treatment

Author Affiliations
  • 1Department of Internal Medicine, Gulhane School of Medicine, Ankara, Turkey
JAMA. 2014;312(16):1693. doi:10.1001/jama.2014.11114

To the Editor Dr Roumie and colleagues1 reported that compared with sulfonylureas the addition of insulin to metformin to improve glycemic control was associated with an increased risk of a composite of nonfatal cardiovascular outcomes and all-cause mortality in patients with diabetes mellitus. Although the results presented require verification in carefully designed clinical trials, we have some concerns about the current analyses.

First Page Preview View Large
First page PDF preview
First page PDF preview
×