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To the Editor In Dr Safford’s Editorial,1 she discussed our analyses2 that quantified how sensitive our conclusions were to unmeasured confounding and used as an example the degree of insulin resistance. We would like to provide a clarification to the explanation provided regarding unmeasured confounder imbalance.
Roumie CL, Greevy RA, Griffin MR. Insulin vs Sulfonylureas for Second-Line Diabetes Treatment. JAMA. 2014;312(16):1694. doi:10.1001/jama.2014.11126