Chubby mice with blond bellies and an artfully disabled gene are giving scientists new insights into factors that can contribute to obesity, according to a new study reported last month (Nat Med. 1999;5:1066-1070).
Besides shedding light on obesity, the rotund rodents are also shedding weight when treated with a drug that helps compensate for the genetic defect, a finding with potential implications for treating obesity in humans.
Stephenson J. Knockout Science: Chubby Mice Provide New Insights Into Obesity. JAMA. 1999;282(16):1507-1508. doi:10.1001/jama.282.16.1507