Author Affiliations: Hematology Service, Clinical Pathology Department (Dr Horne) and the Special Procedures Unit, Radiology Department (Dr Chang), Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD.
Grand Rounds at the Clinical Center of the National
Institutes of Health Section Editors: John I. Gallin, MD, the Clinical
Center of the National Institutes of Health, Bethesda, Md; David S. Cooper,
MD, Contributing Editor, JAMA.
We present the case of a man bedridden by deep venous thrombosis who
was given intraclot instillations of recombinant tissue plasminogen activator
with remarkable improvement. Although such aggressive treatment may be justified
in severe cases, the role for thrombolytic agents for less symptomatic deep
venous thrombosis is undefined. We discuss the question of when thrombolytic
therapy should be considered. However, proper clinical trials are needed before
firm recommendations can be made.
Horne III MK, Chang R. Thrombolytic Therapy for Deep Venous Thrombosis?. JAMA. 1999;282(22):2164-2166. doi:10.1001/jama.282.22.2164