Author Affiliation: Department of Mathematics, Statistics, and Epidemiology, Imperial Cancer Research Fund, London, England.
The human papillomavirus (HPV) has been clearly established as the primary
cause of cervical cancer in nearly all cases.1
Thus, it should not be surprising that testing for HPV should have a role
in measures aimed at control of this disease. The ultimate goal must be eradication
of HPV by vaccination, but a more immediate prospect is the detection and
monitoring of the virus as part of the screening and diagnostic process. Testing
for HPV could have 3 potential roles: triage of patients with atypical squamous
cells of undetermined significance (ASCUS) and low-grade cervical smears;
surveillance of high-grade cervical intraepithelial neoplasia and localized
(micro) invasive disease after treatment; and primary screening—either
alone or in combination with cytology.
Cuzick J. Human Papillomavirus Testing for Primary Cervical Cancer Screening. JAMA. 2000;283(1):108-109. doi:10.1001/jama.283.1.108