Author Affiliations: Oncology Service (Drs J. Shields, Tovilla-Canales, C. Shields, and Mercado), Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pa; and the Department of Pathology, Fox Chase Cancer Center, Philadelphia (Dr Ehya).
Photo/Essay Section Editor: Roxanne K. Young,
Malignant neoplasms occasionally metastasize to intraocular structures.
Most intraocular metastases occur in the uveal tract (iris, ciliary body,
and choroid).1 Metastasis most often develops
in the choroid (88%) and less often in the iris (9%) and ciliary body (3%).2 Metastasis from breast and lung cancers accounts
for most intraocular metastasis.2 In 25%
of patients who present with uveal metastasis, the intraocular lesion represents
the first manifestation of systemic cancer.2
Shields JA, Shields CL, Tovilla-Canales JL, Mercado GV, Ehya H. Breast Carcinoma Metastatic to the Iris. JAMA. 2000;283(2):178. doi:10.1001/jama.283.2.178