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January 12, 2000

Breast Carcinoma Metastatic to the Iris

Author Affiliations

Author Affiliations: Oncology Service (Drs J. Shields, Tovilla-Canales, C. Shields, and Mercado), Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pa; and the Department of Pathology, Fox Chase Cancer Center, Philadelphia (Dr Ehya).


Photo/Essay Section Editor: Roxanne K. Young, Associate Editor.

JAMA. 2000;283(2):178. doi:10.1001/jama.283.2.178

Malignant neoplasms occasionally metastasize to intraocular structures. Most intraocular metastases occur in the uveal tract (iris, ciliary body, and choroid).1 Metastasis most often develops in the choroid (88%) and less often in the iris (9%) and ciliary body (3%).2 Metastasis from breast and lung cancers accounts for most intraocular metastasis.2 In 25% of patients who present with uveal metastasis, the intraocular lesion represents the first manifestation of systemic cancer.2

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