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Contempo Updates
February 9, 2000

Recent Advances in Wound Healing

Author Affiliations

Author Affiliations: Boston University School of Medicine, Boston, Mass.


Contempo Updates Section Editors: Thomas C. Jefferson, MD, Contributing Editor; Stephen J. Lurie, MD, PhD, Fishbein Fellow.

JAMA. 2000;283(6):716-718. doi:10.1001/jama.283.6.716

Over the past decade, a variety of new therapies have become available for patients with acute and chronic wounds. Enthusiasm for these treatments should be tempered by the understanding that treatment of the wound's underlying origin is paramount and that cost and cost-effectiveness should be considered closely.

Wound healing includes 3 overlapping phases: inflammation, tissue formation, and tissue remodeling. This involves a complex, dynamic series of events including clotting, inflammation, granulation tissue formation, epithelialization, neovascularization, collagen synthesis, and wound contraction.1 These events overlap in time, and involve a complex array of cytokines secreted by platelets, macrophages, neutrophils, fibroblasts, and epidermal cells.1

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