Author Affiliations: Departments of Surgery (Drs Bartlett, Younger, and Hirschl) and Pediatrics (Drs Roloff and Custer), University of Michigan Medical Center, Ann Arbor.
The University of Michigan experience with extracorporeal life support
(ECLS) in 1000 consecutive patients between 1980 and 1998 is the largest series
at one institution in the world. Among this patient population, survival to
hospital discharge in moribund patients with respiratory failure was 88% in
586 neonates, 70% in 132 children, and 56% in 146 adults. Survival in moribund
patients with cardiac failure was 48% in 105 children and 33% in 31 adults.
This article describes the University of Michigan's overall ECLS patient experience,
the progression of ECLS from laboratory experiments to clinical application
at the bedside, the expansion of the technology to other centers, and current
ECLS technology and outcomes. Despite the challenges faced in clinical research
in this field, our experience and that of others has shown that ECLS saves
lives of patients with acute cardiac or pulmonary failure in a variety of
Bartlett RH, Roloff DW, Custer JR, Younger JG, Hirschl RB. Extracorporeal Life SupportThe University of Michigan Experience. JAMA. 2000;283(7):904-908. doi:10.1001/jama.283.7.904