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February 23, 2000

Estrogen and Alzheimer DiseasePlausible Theory, Negative Clinical Trial

Author Affiliations

Author Affiliations: National Institute of Child Health and Human Development–Yale Center for the Study of Learning and Attention, Department of Pediatrics, Yale University School of Medicine, New Haven, Conn.

JAMA. 2000;283(8):1055-1056. doi:10.1001/jama.283.8.1055

Whether to use estrogen replacement therapy in postmenopausal women continues to represent a major concern for women and their physicians. In the last few years, it has become clear that estrogen exerts a wide range of effects, including (in addition to its effects on reproduction) effects on the cardiovascular system,1 skeletal system2 and, of particular interest, neuronal systems serving cognitive function, especially memory.37

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