Author Affiliations: National Institute of Child Health and Human Development–Yale Center for the Study of Learning and Attention, Department of Pediatrics, Yale University School of Medicine, New Haven, Conn.
Whether to use estrogen replacement therapy in postmenopausal women
continues to represent a major concern for women and their physicians. In
the last few years, it has become clear that estrogen exerts a wide range
of effects, including (in addition to its effects on reproduction) effects
on the cardiovascular system,1 skeletal system2 and, of particular interest, neuronal systems serving
cognitive function, especially memory.3- 7
Shaywitz BA, Shaywitz SE. Estrogen and Alzheimer DiseasePlausible Theory, Negative Clinical Trial. JAMA. 2000;283(8):1055-1056. doi:10.1001/jama.283.8.1055