Author Affilations: Department of Veterans Affairs Medical Center, Dallas (Drs Spechler and Feldman), University of Texas Southwestern Medical Center (Drs Spechler, Fischbach, and Feldman), School of Public Health (Dr Fischbach); and the University of Texas Health Science Center, Houston (Dr Fischbach).
Helicobacter Pylori organisms have been infecting
human stomachs for centuries. Antigens of these microaerophilic, gram-negative
bacteria have been found in stool samples of ancient mummies.1
Today, it appears that more than half of the world's population is infected
with H pylori.2 These
organisms are adapted for survival in the stomach in which infection causes
a chronic gastritis that persists for decades.
Spechler SJ, Fischbach L, Feldman M. Clinical Aspects of Genetic Variability in Helicobacter pylori. JAMA. 2000;283(10):1264-1266. doi:10.1001/jama.283.10.1264