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March 8, 2000

Clinical Aspects of Genetic Variability in Helicobacter pylori

Author Affiliations

Author Affilations: Department of Veterans Affairs Medical Center, Dallas (Drs Spechler and Feldman), University of Texas Southwestern Medical Center (Drs Spechler, Fischbach, and Feldman), School of Public Health (Dr Fischbach); and the University of Texas Health Science Center, Houston (Dr Fischbach).

JAMA. 2000;283(10):1264-1266. doi:10.1001/jama.283.10.1264

Helicobacter Pylori organisms have been infecting human stomachs for centuries. Antigens of these microaerophilic, gram-negative bacteria have been found in stool samples of ancient mummies.1 Today, it appears that more than half of the world's population is infected with H pylori.2 These organisms are adapted for survival in the stomach in which infection causes a chronic gastritis that persists for decades.

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