Author Affiliations: Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC.
The young intern, Dr O'Connor, is beginning his rotation in the cardiac
care unit in 1983. His faculty attending, Dr Califf, notices that Dr O'Connor
has initiated β-blockade in a patient with heart failure. The discussion
that ensues does not reflect positively on Dr O'Connor's future career. In
2000, both physicians realize that their understanding of blockade of the β-receptor
as a simple matter of reducing myocardial contractility was shortsighted and
fundamentally incorrect. Dr O'Connor had initiated the right therapy but for
the wrong reason.
Califf RM, O'Connor CM. β-Blocker Therapy for Heart FailureThe Evidence Is In, Now the Work Begins. JAMA. 2000;283(10):1335-1337. doi:10.1001/jama.283.10.1335