March 8, 2000

β-Blocker Therapy for Heart FailureThe Evidence Is In, Now the Work Begins

Author Affiliations

Author Affiliations: Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC.

JAMA. 2000;283(10):1335-1337. doi:10.1001/jama.283.10.1335

The young intern, Dr O'Connor, is beginning his rotation in the cardiac care unit in 1983. His faculty attending, Dr Califf, notices that Dr O'Connor has initiated β-blockade in a patient with heart failure. The discussion that ensues does not reflect positively on Dr O'Connor's future career. In 2000, both physicians realize that their understanding of blockade of the β-receptor as a simple matter of reducing myocardial contractility was shortsighted and fundamentally incorrect. Dr O'Connor had initiated the right therapy but for the wrong reason.

First Page Preview View Large
First page PDF preview
First page PDF preview