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Books, Journals, New Media
April 5, 2000

LipoproteinsLipoproteins in Health and Diseases

Author Affiliations
 

Harriet S.MeyerMD, Contributing EditorJonathan D.EldredgeMLS, PhD, Journal Review EditorRobertHoganMD, adviser for new media

 

Not Available

 

edited by D. J. Betteridge, D. R. Illingworth, and J. Shepherd, 1302 pp, with illus, $225, ISBN 0-340-55269-7, London, UK, Arnold/Hodder Headline Group, New York, NY, Oxford University Press, 1999.

JAMA. 2000;283(13):1753-1754. doi:10.1001/jama.283.13.1753

As the first comprehensive textbook on the title subject, this reference work fills an important void. The volume consists of 1300 pages divided among 73 chapters by 93 authors, which are presented in six major sections.

The first section, "Plasma Lipoproteins: Chemistry and Biology," deals with the structure and function of lipoproteins. The second section, "Regulation of Lipoprotein Metabolism," discusses the physiology of lipoprotein transport and is subdivided into sections dealing specifically with genetics, enzymes, and receptors. "Laboratory Techniques" contains excellent chapters devoted to the identification and separation of lipoproteins, apoproteins, receptors, and enzymes, together with techniques for turnover studies and kinetics. "Atherosclerosis: Causes and Consequences" elucidates the pathophysiology and epidemiology of lipoproteins and coronary heart disease and discusses the results of randomized controlled trials. "Dyslipidemia: Primary and Secondary" describes the epidemiology, biochemistry and genetics, pathophysiology, and treatment of primary lipid disorders ranging from the common (eg, familial combined hyperlipidemia) to the rare (Tangier disease). A thorough discussion of secondary dyslipidemia is also part of this section. The last section, "Treatment," includes one chapter on diet therapy, five chapters on each of the major pharmacologic classes of drugs currently available, and one chapter each on combination drug therapy, cost-effectiveness, low-density lipoprotein aphereses, and pediatrics.

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