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Consensus Statement
April 19, 2000

Meta-analysis of Observational Studies in EpidemiologyA Proposal for Reporting

Author Affiliations

Author Affiliations: Centers for Disease Control and Prevention, Atlanta, Ga (Drs Stroup, Williamson, and Thacker); University of Pennsylvania School of Medicine, Philadelphia (Dr Berlin); RAND Corporation, Santa Monica (Dr Morton), University of California, San Francisco (Dr Rennie), Stanford University, Stanford (Dr Olkin), Calif; JAMA, Chicago, Ill (Dr Rennie); Thomas C. Chalmers Centre for Systematic Reviews, Children's Hospital of Eastern Ontario Research Institute, Ottawa (Mr Moher); Michigan State University, East Lansing (Dr Becker); and Georgia State University, Atlanta (Dr Sipe).

JAMA. 2000;283(15):2008-2012. doi:10.1001/jama.283.15.2008
Objective

Objective Because of the pressure for timely, informed decisions in public health and clinical practice and the explosion of information in the scientific literature, research results must be synthesized. Meta-analyses are increasingly used to address this problem, and they often evaluate observational studies. A workshop was held in Atlanta, Ga, in April 1997, to examine the reporting of meta-analyses of observational studies and to make recommendations to aid authors, reviewers, editors, and readers.

Participants Twenty-seven participants were selected by a steering committee, based on expertise in clinical practice, trials, statistics, epidemiology, social sciences, and biomedical editing. Deliberations of the workshop were open to other interested scientists. Funding for this activity was provided by the Centers for Disease Control and Prevention.

Evidence We conducted a systematic review of the published literature on the conduct and reporting of meta-analyses in observational studies using MEDLINE, Educational Research Information Center (ERIC), PsycLIT, and the Current Index to Statistics. We also examined reference lists of the 32 studies retrieved and contacted experts in the field. Participants were assigned to small-group discussions on the subjects of bias, searching and abstracting, heterogeneity, study categorization, and statistical methods.

Consensus Process From the material presented at the workshop, the authors developed a checklist summarizing recommendations for reporting meta-analyses of observational studies. The checklist and supporting evidence were circulated to all conference attendees and additional experts. All suggestions for revisions were addressed.

Conclusions The proposed checklist contains specifications for reporting of meta-analyses of observational studies in epidemiology, including background, search strategy, methods, results, discussion, and conclusion. Use of the checklist should improve the usefulness of meta-analyses for authors, reviewers, editors, readers, and decision makers. An evaluation plan is suggested and research areas are explored.

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