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June 28, 2000

Do Statins Prevent Both Cardiovascular Disease and Fracture?

Author Affiliations

Author Affiliations: Departments of Medicine, and Epidemiology and Biostatistics, University of California, San Francisco.

JAMA. 2000;283(24):3255-3257. doi:10.1001/jama.283.24.3255

Two articles in this issue of THE JOURNAL1,2 report that 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins) that reduce blood cholesterol levels and the risk of cardiovascular disease3 also might substantially reduce the risk of fractures. The studies are impressively large and well done, and some clinicians might be tempted to prescribe statins in the hope of preventing or treating osteoporosis. However, these are observational studies, not randomized trials, and they do not provide enough certainty for clinicians to begin prescribing statins to reduce fracture risk.

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