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August 23/30, 2000

Medications for Alcohol Dependence—New Vistas

Author Affiliations

Author Affiliation: Alcohol Research Center, University of Connecticut School of Medicine, Farmington.

JAMA. 2000;284(8):1016-1017. doi:10.1001/jama.284.8.1016

Since its approval by the Food and Drug Administration in 1949, the aversive agent disulfiram1 was, for nearly 50 years, the only drug approved in the United States to treat alcohol dependence. However, in 1994, the Food and Drug Administration approved naltrexone, an opioid antagonist, for that indication based largely on the results of 2 federally funded studies.2,3 The approval of naltrexone for alcoholism treatment has also increased interest on the part of the pharmaceutical industry in medications to treat alcohol dependence.

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