For three decades, coronary artery bypass grafting has been a lifesaver
for millions of Americans. But it comes with a trade-off: up to 8% of patients
who have bypass surgery experience impaired kidney function.
In a new study, researchers at Duke University Medical Center suggest
an intriguing genetic link that apparently protects kidney function after
bypass surgery. Following up on their previous findings that the E4 variant of the apolipoprotein (APO) gene
was linked with increased cognitive decline following bypass surgery, the
researchers tracked blood levels of creatinine in 564 patients after they
had such surgery. They compared creatinine levels with the patients' APOE variants.
Gene Protects Kidneys. JAMA. 2000;284(8):951. doi:10.1001/jama.284.8.951